MIB-1 and p27Kip1 expression in nephroblastoma.
نویسندگان
چکیده
منابع مشابه
Quantitative analysis of the decay of immunoreactivity in stored prostate needle biopsy sections.
Application of immunohistochemistry to assess the presence of prognostic tissue markers is used widely. The quantitation of these markers may be hampered by a time-related loss of antigenicity in formalin-fixed paraffin-embedded tissue stored on glass slides. Potential loss of immunohistochemical staining intensity was studied on prostatic needle biopsy sections stored for a maximum of 4 years ...
متن کاملMIB-1 (KI-67) Proliferation Index and Cyclin-Dependent Kinase Inhibitor p27 Protein Expression in Nephroblastoma
Purpose: A number of studies have indicated that the tumor proliferation marker MIB-1 and cell cycle inhibitor p27 expression are of prognostic importance in a variety of cancers. The present study was performed to evaluate the prognostic value of these molecules in Wilms’ tumors. Experimental Design: MIB-1 and p27 expressions were investigated by the means of immunohistochemical analysis of 62...
متن کاملMIB-1 (KI-67) proliferation index and cyclin-dependent kinase inhibitor p27(Kip1) protein expression in nephroblastoma.
PURPOSE A number of studies have indicated that the tumor proliferation marker MIB-1 and cell cycle inhibitor p27(Kip1) expression are of prognostic importance in a variety of cancers. The present study was performed to evaluate the prognostic value of these molecules in Wilms' tumors. EXPERIMENTAL DESIGN MIB-1 and p27(Kip1) expressions were investigated by the means of immunohistochemical an...
متن کاملp27Kip1 is expressed in proliferating cells in its form phosphorylated on threonine 187
BACKGROUND: G1/S cell cycle progression requires p27Kip1 (p27) proteolysis, which is triggered by its phosphorylation on threonine (Thr) 187. Since its levels are abundant in quiescent and scarce in cycling cells, p27 is an approved marker for quiescent cells, extensively used in histopathology and cancer research. METHODS: However here we showed that by using a specific phosphorylation site (p...
متن کاملSteroid hormone receptors, MIB-1, p53, and c-erb-B2 expression on breast cancer: Comparison of immunohistochemistry on cell block and fine needle aspiration and tissue sample, in northwest Iran
Background: Fine-needle aspiration of breast cancer often provides moderate cellular material that is representative of the tumors. These samples can be used not only for cytological diagnosis but also to obtain information on the prognosis and likely response to therapy by using immunohistochemical staining studies. Methods: We assessed the degree of correlation between prognostic biologic ma...
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عنوان ژورنال:
- Clinical cancer research : an official journal of the American Association for Cancer Research
دوره 10 22 شماره
صفحات -
تاریخ انتشار 2004